UK Issues New Warnings for Antidepressant Side Effects

A BBC health expert has issued a stark reminder to UK patients taking antidepressants, warning of two serious side effects linked to commonly prescribed SSRIs. Doctor Ranj Singh, appearing on BBC Morning Live, highlighted that fluoxetine, sertraline, and citalopram — the most widely used antidepressants — may cause suicidal thoughts and sexual dysfunction, which can persist even after stopping medication ^[1].

The NHS confirms SSRIs work by increasing serotonin levels in the brain, which can help reduce stress and negative thoughts ^[1]. However, the medication’s risks are now being more clearly communicated. The UK Government announced new safety measures following a detailed review involving patients and families.

These changes include a new boxed warning in patient information leaflets (PILs), a dedicated patient card, and an ancillary safety leaflet. The term 'post SSRI sexual dysfunction (PSSD)' is now being added to PILs for some antidepressants ^[1].

Healthcare professionals are advised to inform patients about the need to seek urgent medical help if new or worsening suicidal thoughts arise, especially when starting or adjusting doses ^[1]. Support options include NHS 111, local mental health crisis teams, Samaritans (116 123), or texting ‘SHOUT’ to 85258.

The advice applies to all SSRIs, including citalopram for depression and panic disorder, sertraline for OCD, PTSD, and social anxiety, and fluoxetine for depression, bulimia, and menopause symptoms ^[1]. Patients are strongly urged not to alter their medication without professional guidance ^[2]. The story was first reported by Mirror and Daily Star.